Vaccine, rabies: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Intramuscular
Preexposure prophylaxis against rabies

Adult: Primary immunisation: 1 mL on days 0, 7 and 28 (3rd dose may be given on day 21 if needed). Booster: Persons at regular or continuous risk: 1 mL given 1 year after completion of primary course, then 1 mL every 3-5 years. Persons at intermittent risk: Doses are given according to official recommendations.
Child: Same as adult dose.

Intramuscular
Postexposure prophylaxis of rabies

Adult: Unimmunised or incompletely immunised persons: 1 mL on days 0, 3, 7, 14, and 28; alternatively, the 5th dose may be given on day 30. Fully immunised persons: 1 mL on day 0 and 3.
Child: Same as adult dose.

Contraindications

Hypersensitivity (when used for pre-exposure prophylaxis). Severe immunosuppression.

Special Precautions

Patient with acute or minor illness, personal or family history of febrile convulsions, history of bleeding disorders (e.g. thrombocytopenia). Postpone vaccination in case of febrile or acute illness. Very premature infants or those with history of respiratory immaturity. Children. Pregnancy and lactation.

Adverse Reactions

Significant: Serum sickness, syncope, bleeding haematoma, multiple sclerosis, meningitis, myelitis, retrobulbar neuritis, convulsion, transient paralysis. Rarely, Guillain-Barre syndrome.
Blood and lymphatic system disorders: Lymphadenopathy.
Gastrointestinal disorders: Abdominal pain, diarrhoea, nausea, vomiting.
General disorders and administration site conditions: Inj site reactions (e.g. bruising, pruritus, erythema, induration), pyrexia, malaise, chills, irritability.
Musculoskeletal and connective tissue disorders: Arthralgia, myalgia.
Nervous system disorders: Dizziness, headache.
Respiratory, thoracic and mediastinal disorders: Dyspnoea, wheezing.
Potentially Fatal: Anaphylactoid or hypersensitivity reactions, encephalitis.

Pregnancy Category (US FDA)

IM/Parenteral: C

Drug Interactions

Diminished efficacy when given with antimalarials, corticosteroids, and other immunosuppressants. Increased risk of bleeding or haematoma with anticoagulants.

Action

Description: Rabies vaccine is an inactivated virus vaccine that is used for active immunisation against rabies. It promotes immunity by inducing an active immune response. It can be used for pre- and post-exposure immunisation. For post-exposure immunisation, it is often used in conjunction with rabies immunoglobulins as it takes about 7-10 days for the specific antibodies to develop.
Onset: IM: Rabies antibody: Approx 7-10 days.
Duration: ≥1 year.

Storage

Store between 2-8°C. Do not freeze. Protect from light.
Any unused portions should be disposed of in accordance with local requirements.

MIMS Class

Vaccines, Antisera & Immunologicals

ATC Classification

J07BG - Rabies vaccines ; Used for active immunizations.

References

Anon. Rabies Vaccine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/07/2018 .

Buckingham R (ed). Rabies Vaccines. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/07/2018.

Joint Formulary Committee. Rabies Vaccine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/07/2018.

Rabavert (GlasoSmithKline Biologicals SA). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/07/2018.

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